| Sesamin & Lingnas In Fish Oil Study Abstract of Sesamin and omega 3 fatty acids as a combination supplement and how scientist have documented the amazing benefits how they work together in the anti-inflammatory war...... learn how Sealogix is above any other PGFO ....
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka,
Japan.
The effects of sesamin, a lignan from sesame oil, on various aspects of cholesterol
metabolism were examined in rats maintained on various dietary regimens. When given
at a dietary level of 0.5% for 4 weeks, sesamin reduced the concentration of serum
and liver cholesterol significantly irrespective of the presence or absence of cholesterol
in the diet, except for one experiment in which the purified diet free of cholesterol
was given. On feeding sesamin, there was a decrease in lymphatic absorption of cholesterol
accompanying an increase in fecal excretion of neutral, but not acidic, steroids,
particularly when the cholesterol-enriched diet was given.
Benefits ......
Sesamin inhibited micellar
solubility of cholesterol, but not bile acids, whereas it neither bound taurocholate
nor affected the absorption of fatty acids. Only a marginal proportion (ca. 0.15%)
of sesamin administered intragastrically was recovered in the lymph. There was a
significant reduction in the activity of liver microsomal 3-hydroxy-3-methylglutaryl
coenzyme A reductase after feeding sesamin, although the activity of hepatic cholesterol
7 alpha-hydroxylase, drug metabolizing enzymes, and alcohol dehydrogenase remained
uninfluenced. Although the weight and phospholipid concentration of the liver increased
unequivocally on feeding sesamin, the histological examination by microscopy showed
no abnormality, and the activity of serum GOT and GPT remained unchanged. Since
sesamin lowered both serum and liver cholesterol levels by inhibiting absorption
and synthesis of cholesterol simultaneously, it deserves further study as a possible
hypocholesterolemic agent of natural origin.
Ikeda S, Kagaya M, Kobayashi K, et al. Dietary sesame lignans
decrease lipid peroxidation in rats fed docosahexaenoic acid. J Nut Sci Vitaminol
(Tokyo). 2003 Sep;49(4):270-6.
Sesamin & Lingnas In Fish Oil Study Abstract
Department of Food and Nutrition, Sugiyama Jogakuen University, Nagoya 464-8662,
Japan.
We have previously reported that dietary sesamin and sesaminol, major lignans of
sesame seed, elevate the alpha-tocopherol concentration and decrease the thiobarbituric
acid reactive substance (TBARS) concentration in the plasma and liver of rats. In
this study, the effects of dietary sesamin and sesaminol on the lipid peroxidation
in the plasma and tissues of rats fed docosahexaenoic acid (DHA, 22:6 n-3) were
examined. Male Wistar rats (4-wk-old) were divided into the following six experimental
groups: control group, fed a basal diet: sesamin group, fed a diet with sesamin
(2 g/kg); sesaminol group, fed a diet with sesaminol (2 g/kg); DHA group, fed a
diet containing DHA (5 g/kg); DHA + sesamin group, fed a diet containing DHA with
sesamin; and DHA + sesaminol group, fed a diet containing DHA with sesaminol.
Sesamin & Lingnas In Fish Oil What It Does
Each
diet contained either 0.01 or 0.05 g D-alpha-tocopherol/kg, and the rats were fed
the respective experimental diet for 5 wk. The dietary DHA elevated the TBARS concentration
and also increased the red blood-cell hemolysis induced by the dialuric acid. The
dietary sesamin and sesaminol lowered the TBARS concentrations and decreased the
red blood hemolysis. The dietary sesamin and sesaminol elevated the alpha-tocopherol
concentrations in the plasma, liver, and brain of the rats fed a diet with or without
DHA. These results suggest that dietary sesame lignans decrease lipid peroxidation
as a result of elevating the alpha-tocopherol concentration in rats fed DHA.
Kang MH, Kawai Y, Naito M, Osawa T. Dietary defatted sesame flour
decreases susceptibility to oxidative stress in hypercholesterolemic rabbits. J
Nutr. 1999 Nov;129(10):1885-90.
Sesamin & Lingnas In Fish Oil Study Abstract
Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural
Sciences, Nagoya 464-8601, Japan.
Plant glucosides possess antioxidative properties due to their ability to scavenge
free radicals. Sesame seeds contain a class of these compounds, the sesaminol glucosides.
To evaluate their antioxidative activity in vivo, we fed rabbits diets containing
1% cholesterol (Chol) with or without 10% defatted sesame flour (DSF) (containing
1% sesaminol glucosides) for 90 d. We determined the susceptibility of their tissues
to oxidation ex vivo as well as serum total cholesterol (TC), phospholipid (PL),
triglyceride (TG) and HDL cholesterol (HDL-C) concentrations. Serum TC, HDL-C, PL
and TG levels were unaffected by the addition of DSF. The HDL-C in the Chol + DSF
group was greater than in the Chol group at 45 d. Both were greater than in the
groups that did not consume cholesterol. Liver TC and TG were significantly lower
in rabbits fed the diet containing DSF plus 1% cholesterol than in those fed 1%
cholesterol alone.
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Lipid peroxidation activity, measured as 2-thiobarbituric acid
reactive substances (TBARS), was lower in the liver (P < 0.05) and serum (P =
0.06) of rabbits fed DSF plus cholesterol than in rabbits fed the cholesterol diet.
Although we did not detect sesaminol glucosides in peripheral tissues, we observed
abundant quantities of sesaminol in rabbits fed DSF, the principal metabolite. Our
findings suggest that feeding DSF to rabbits does not protect cholesterol-induced
hypercholesterolemia, but may decrease susceptibility to oxidative stress in rabbits
fed cholesterol, perhaps due to the antioxidative activity of sesaminol.
Nakabayashi A, Kitagawa Y, Suwa Y, et al. Alpha-tocopherol enhances
the hypocholesterolemic action of sesamin in rats. Int J Vitam Nutr Res. 1995;65(3):162-8.
Sesamin & Lingnas In Fish Oil Study Abstract
Institute for Biomedical Research, Suntory Ltd., Osaka, Japan.
The effect of alpha-tocopherol on the hypocholesterolemic action of sesamin was
examined in rats given a cholesterol-enriched diet. When different levels (0.05
and 0.2%) of sesamin were fed, the supplementation of 1% alpha-tocopherol significantly
accentuated the hypocholesterolemic action of sesamin, particularly with the higher
sesamin level, although alpha-tocopherol alone did not affect the concentration
of serum cholesterol. The dose-dependent promoting effect of alpha-tocopherol on
the hypocholesterolemic action of sesamin was confirmed by supplementing different
levels (0.2 and 1%) of alpha-tocopherol to a fixed level of sesamin (0.2%). alpha-Tocopherol
was still effective at the 0.2% level. The metabolism of sesamin in the liver S9
fraction appeared to be interfered with alpha-tocopherol in vitro, suggesting a
possible role of alpha-tocopherol in maintenance of the availability of sesamin.
Sankar D, Sambandam G, Ramakrishna RM, Pugalendi KV. Modulation
of blood pressure, lipid profiles and redox status in hypertensive patients taking
different edible oils. Clin Chim Acta. 2005 May;355(1-2):97-104.
Sesamin & Lingnas In Fish Oil Study Abstract
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608
002, Tamilnadu, India. devsankara@hotmail.com
BACKGROUND: Free oxygen radicals and insufficiency of antioxidants have been implicated
in the pathogenesis of hypertension. We determined the effect of edible oils on
blood pressure, lipid profiles and redox status in hypertensive patients given antihypertensive
therapy (nifedipine-calcium channel blocker). METHODS: 530 patients medicated with
nifedipine were divided into 3 groups (356 patients-sesame oil; 87 patients-sunflower
oil; 47 patients-groundnut oil) and the control group (n=40) received only the drug,
nifedipine. The respective oils were supplied to the patients and instructed to
use as the only edible oil for 60 days, which comes to 35 g of oil/day/person. Blood
pressure, lipid profiles [total cholesterol (TC), low density lipoprotein cholesterol
(LDL-C), high density lipoprotein cholesterol (HDL-C) and triglycerides (TG)], lipid
peroxidation [thiobarbituric acid reactive substances (TBARS)], enzymatic [superoxide
dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] and nonenzymatic
[(vitamin C, vitamin E, beta-carotene and reduced glutathione (GSH)] in blood were
measured at baseline and after 60 days of oil substitution. RESULTS: Patients with
nifedipine alone or with respective oils had significantly lowered blood pressure.
Sesamin & Lingnas In Fish Oil The Sesamin Omega.....
TC, LDL-C and TG decreased while HDL-C elevated in sesame and sunflower oil groups.
Increases of HDL-C and TG were noted in groundnut oil group. TBARS levels reduced
in all the groups whereas the reduction was remarkable in sesame oil group. Activities
of SOD elevated in the 3 oil groups whereas GPx and CAT increased only in sesame
oil group. Levels of vitamin C, vitamin E, beta-carotene and GSH increased in sesame
oil group whereas vitamin E and beta-carotene were elevated only in sunflower and
groundnut oil groups. GSH increased in drug control group also. CONCLUSION: Among
the 3 oils, sesame oil offers better protection over blood pressure, lipid profiles
and lipid peroxidation and increases enzymatic and nonenzymatic antioxidants.
Shimizu S, Akimoto K, Shinmen Y, et al. Sesamin is a potent and
specific inhibitor of delta 5 desaturase in polyunsaturated fatty acid biosynthesis.
Lipids. 1991 Aug;26(7):512-6.
Sesamin & Lingnas In Fish Oil Study Abstract and proff of health benefits ......
Department of Agricultural Chemistry, Kyoto University, Japan.
Incubation with sesame oil increases the mycelial dihomo-gamma-linolenic acid content
of an arachidonic acid-producing fungus, Mortierella alpina, but decreases its arachidonic
acid content [Shimizu, S., K. Akimoto, H. Kawashima, Y. Shinmen and H. Yamada (1989)
J. Am. Oil Chem. Soc. 66, 237-241]. The factor causing these effects was isolated
and identified to be (+)-sesamin. The results obtained in experiments with both
a cell-free extract of the fungus and with rat liver microsomes demonstrated that
(+)-sesamin specifically inhibits delta 5 desaturase at low concentrations, but
does not inhibit delta 6, delta 9 and delta 12 desaturases. Kinetic analysis showed
that (+)-sesamin is a noncompetitive inhibitor (Ki for rat liver delta 5 desaturase,
155 microM). (+)-Sesamolin, (+)-sesaminol and (+)-episesamin also inhibited only
delta 5 desaturases of the fungus and liver. These results demonstrate that (+)-sesamin
and related lignan compounds present in sesame seeds or its oil are specific inhibitors
of delta 5 desaturase in polyunsaturated fatty acid biosynthesis in both microorganisms
and animals.
Yamashita K, Ikeda S, Obayashi M. Comparative effects of flaxseed
and sesame seed on vitamin E and cholesterol levels in rats. Lipids. 2003 Dec;38(12):1249-55
Sesamin & Lingnas In Fish Oil Study Abstract
Department of Food and Nutrition, Sugiyama Jogakuen University, School of Life Studies,
Nagoya 464-8662, Japan. kanaey@food.sugiyama-u.ac.jp
Flaxseed and sesame seed both contain more than 40% fat, about 20% protein, and
vitamin E, mostly gamma-tocopherol. Furthermore, both contain considerable amounts
of plant lignans. However, flaxseed contains 54% alpha-linolenic acid, but sesame
seed only 0.6%, and the chemical structures of flaxseed and sesame lignans are different.
In this study, we investigated the differential effects of flaxseed and sesame seed
on plasma and tissue gamma-tocopherol, TBARS, and cholesterol concentrations. Rats
were fed experimental diets for 4 wk: vitamin E-free, (-VE), gamma-tocopherol, flaxseed
(FS), sesame seed (SS), flaxseed oil (FO), FO with sesamin (FOS), and defatted flaxseed
(DFF).
sesame seed & omega 3 supplementation helps in these ways.........
SS and FOS diets induced significantly higher gamma-tocopherol concentrations
in plasma and liver compared with FS, FO, and DFF diets. Groups fed FS, FO, and
FOS showed lower plasma total cholesterol compared with the SS and DFF groups. Higher
TBARS concentrations in plasma and liver were observed in the FS and FO groups but
not in the FOS group. These results suggest that sesame seed and its lignans induced
higher gamma-tocopherol and lower TBARS concentrations, whereas flaxseed lignans
had no such effects. Further, alpha-linolenic acid produced strong plasma cholesterol-lowering
effects and higher TBARS concentrations.
Blood Vessels
Kita S, Matsumura Y, Morimoto S, et al. Antihypertensive effect
of sesamin. II. Protection against two-kidney, one-clip renal hypertension and cardiovascular
hypertrophy. Biol Pharm Bull. 1995 Oct;18(9):1283-5.
Sesamin & Lingnas In Fish Oil Study Abstract
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan.
We investigated the antihypertensive effect of sesamin, a lignan from sesame oil,
using two-kidney, one-clip (2K,1C) renal hypertensive rats. After clipping the left
renal artery, animals were assigned to either a normal diet group (control group)
or a sesamin-containing (1% (w/w)) diet group (sesamin group). The sham-operated
rats (sham group) were fed a normal diet and tap water. The systolic blood pressure
of the control group increased progressively in comparison with the sham group.
This 2K,1C-induced hypertension was markedly reduced by feeding the sesamin-containing
diet. The systolic blood pressure after 4 weeks was 123.60 +/- 4.01 mmHg in the
sham group, 187.43 +/- 5.69 mmHg in the control group and 145.57 +/- 6.78 mmHg in
the sesamin group, respectively. There were significant increases in left ventricle
plus septum weight-body weight ratio in the control group compared with the sham
group.
Sesamin is proven to work better then just a plain PGFO
This rise was also significantly reduced in the sesamin group. When the thoracic
aorta was histochemically evaluated, the wall thickness and wall-to-lumen ratio
in the control group were significantly increased, compared with the sham group,
indicating that vascular hypertrophy had occurred in the control group. The sesamin
diet tended to ameliorate this vascular hypertrophy, although its effect was not
statistically significant. These findings suggest that sesamin is useful as prophylactic
treatment to combat the development of renal hypertension and cardiac hypertrophy.
Matsumura Y, Kita S, Morimoto S, et al. Antihypertensive effect
of sesamin. I. Protection against deoxycorticosterone acetate- salt-induced hypertension
and cardiovascular hypertrophy. Biol Pharm Bull. 1995 Aug;18(7):1016-9.
Sesamin & Lingnas In Fish Oil Study Abstract
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Osaka,
Japan.
We investigated the antihypertensive effect of sesamin, a lignan from sesame oil,
using deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The animals were
unilaterally nephrectomized, and then separated into a sham-operated group (sham
group) and a DOCA-salt-treated group. The latter was further separated into a normal
diet group (control group) and a sesamin-containing diet group (sesamin group).
The systolic blood pressure of control group progressively increased in comparison
with that of sham group. This DOCA-salt-induced hypertension was markedly suppressed
by feeding a sesamin-containing diet. Systolic blood pressure after 5 weeks was
130.6 +/- 1.9 mmHg in the sham group, 198.1 +/- 7.3 mmHg in the control group and
152.5 +/- 8.4 mmHg in the sesamin group, respectively.
Sesamin studies provide evidence on why it works better ....
The treatment with DOCA and
salt for 5 weeks significantly increased the weight of the left ventricle plus the
septum. However, this increase was significantly suppressed in the sesamin group.
When the degree of vascular hypertrophy of the aorta and superior mesenteric artery
was histochemically evaluated, there were significant increases in wall thickness,
wall area and the wall-to-lumen ratio in the control group, compared with the sham.
Sesamin feeding ameliorated the development of DOCA-salt-induced vascular hypertrophy
in both the aorta and mesenteric artery. These findings strongly suggest that sesamin
is useful as a prophylactic treatment in the development of hypertension and cardiovascular
hypertrophy.
Matsumura Y, Kita S, Tanida Y, et al. Anti- hypertensive effect
of sesamin. III. Protection against development and maintenance of hypertension
in stroke-prone spontaneously hypertensive rats. Biol Pharm Bull. 1998 Jun;21(5):469-73.
Sesamin & Lingnas In Fish Oil Study Abstract
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki,
Japan.
The antihypertensive effect of sesamin, a lignan from sesame oil, was examined using
salt-loaded and unloaded stroke-prone spontaneously hypertensive rats (SHRSP). The
animals at 6 weeks of age were separated into a salt-loaded group and an unloaded
group. Salt-loaded animals were maintained on 1% NaCl drinking water. Each group
was further divided into two groups: normal-diet group and sesamin-diet group. Systolic
blood pressure of all animals was monitored once weekly. At the end of the feeding
periods, cardiovascular hypertrophy and renal damage were evaluated. In the salt-loaded
group, sesamin feeding significantly suppressed the development of hypertension,
and efficient suppression was maintained from 9 to 26 weeks (e.g., 215+/-4 vs. 180+/-4
mmHg, at 17 weeks old).
Sesamin is by far the most powerful additive in a single fish oil supplement......
The left ventricle plus septum weight-to-body weight ratio
was slightly but significantly lowered by sesamin feeding. When the degree of vascular
hypertrophy of the aorta and superior mesenteric artery was histochemically evaluated,
wall thickness and wall area of these vessels were significantly decreased by the
sesamin feeding. Histological renal damage such as thickening of the tunica intima
and fibrinoid degeneration of the arterial wall were often observed in the normal-diet
group, but this damage was efficiently reduced in the sesamin-fed animals. On the
other hand, in the salt-unloaded group, only a slight and nonsignificant suppressive
effect of sesamin on the development of hypertension was observed. Although the
wall area of the aorta was significantly decreased by the sesamin feeding, other
vascular parameters were not ameliorated. The incidence of histological renal damage
tended to decrease in sesamin-fed animals, but these alterations were not statistically
significant. Thus, sesamin feeding was much more effective as an antihypertensive
regimen in salt-loaded SHRSP than in unloaded SHRSP, thereby suggesting that sesamin
is more useful as a prophylactic treatment in the malignant status of hypertension
and/or hypertension followed by water and salt retention.
Matsumura Y, Kita S, Ohgushi R, Okui T. Effects of sesamin on
altered vascular reactivity in aortic rings of deoxycorticosterone acetate-salt-induced
hypertensive rat. Biol Pharm Bull. 2000 Oct;23(9):1041-5.
Sesamin & Lingnas In Fish Oil Study Abstract
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki,
Japan. matumrh@oysun01.oups.ac.jp
The effect of sesamin, a lignan from sesame oil, on altered vasodilator and vasoconstrictor
responses in aortic rings from deoxycorticosterone acetate (DOCA)-salt-induced hypertensive
rats, were examined. The systolic blood pressure after 5-weeks DOCA-salt treatment
was 195.0+/-2.8 mmHg, which was much higher than that of sham-operated control animals
(131.2+/-2.4 mmHg). Sesamin feeding significantly suppressed the development of
this hypertension (167.1+/-8.6 mmHg). Acetylcholine (ACh)-induced endothelium-dependent
relaxation of aortic rings was markedly decreased in the DOCA-salt hypertensive
animals, compared with cases of the control (pD2, 7.0+/-0.1; maximal response, 64.8+/-3.4%
versus pD2, 7.7+/-0.2; maximal response, 93.3+/-2.7%). These changes were partially
but significantly improved by the sesamin feeding. This improvement seems to be
related to a nitric oxide (NO)-dependent component of ACh-induced action, because
sesamin feeding did not affect the responses to ACh in the presence of NO synthase
inhibitor.
Sesamin is the best ingredient found in fish oils ......
A spontaneous NO releaser (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
(NOR 3) which exerts endothelium-independent vasodilatation, produced the same patterns
of responses as those observed with ACh in cases of DOCA-salt treatment and sesamin
feeding. Phenylephrine-induced vasoconstriction was enhanced by the DOCA-salt treatment,
both in preparations with and without endothelium, but these enhancements were almost
completely normalized by sesamin feeding. Thus, dietary sesamin could efficiently
improve the abnormal vasodilator and vasoconstrictor responses in DOCA-salt hypertensive
animals. These effects may contribute to the antihypertensive activity of sesamin.
Nakano D, Kwak CJ, Fujii K, et al. Sesamin metabolites induce
an endothelial nitric oxide-dependent vasorelaxation through their antioxidative
property-independent mechanisms: possible involvement of the metabolites in the
antihypertensive effect of sesamin. J Pharmacol Exp Ther. 2006 Jul;318(1):328-35.
Sesamin & Lingnas In Fish Oil Study Abstract
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1
Nasahara, Takatsuki, Osaka 569-1094 Japan.
Sesamin, a major lignan in sesame seeds and oil, has been known to
lower blood pressure in several types of experimental hypertensive
animals. A recent study demonstrated that sesamin metabolites had in
vitro radical-scavenging activities. Thus, we determined whether the
antioxidative effect of sesamin metabolites modulate the vascular tone
and contribute to the in vivo antihypertensive effect of sesamin. We
used four demethylated sesamin metabolites: SC-1m (piperitol), SC-1
(demethylpiperitol), SC-2m
[(1R,2S,5R,6S)-6-(4-hydroxy-3-methoxyphenyl)-2-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3,3,0]octane],
and SC-2 [(1R,2S,5R,
6S)-2,6-bis(3,4-dihydroxyphenyl)-3,7-dioxabicyclo-[3,3,0]octane]. SC-1,
SC-2m, and SC-2, but not SC-1m, exhibited potent radical-scavenging
activities against the xanthine/xanthine oxidase-induced superoxide
production.
Case prove studies fish oils works ...
On the other hand, SC-1m, SC-1, and SC-2m produced
endothelium-dependent vasorelaxation in phenylephrine-precontracted rat
aortic rings, whereas SC-2 had no effect. The SC-1m- and SC-1-induced
vasorelaxations were markedly attenuated by pretreatment with a nitric
oxide synthase (NOS) inhibitor, NG-nitro-L-arginine (NOARG), or a
soluble guanylate cyclase inhibitor,
1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one. Neither SC-1m nor SC-1
changed the expression level of endothelial NOS protein in aortic
tissues. The antihypertensive effects of sesamin feeding were not
observed in chronically NOARG-treated rats or in deoxycorticosterone
acetate-salt-treated endothelial NOS-deficient mice. These findings
suggest that the enhancement of endothelium-dependent vasorelaxation
induced by sesamin metabolites is one of the important mechanisms of
the in vivo antihypertensive effect of sesamin.
Nakano D, Itoh C, Takaoka M, et al. Antihypertensive effect of
sesamin. IV. Inhibition of vascular superoxide production by sesamin. Biol Pharm
Bull. 2002 Oct;25(9):1247-9.
Sesamin & Lingnas In Fish Oil Study Abstract
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki,
Japan.
We previously demonstrated the preventive effect of sesamin, a lignan from sesame
oil, on the development of several experimental models of hypertension. In the present
study, we explored the mechanisms underlying the antihypertensive effect of sesamin
using the deoxycorticosterone acetate (DOCA)-salt rat hypertensive model. After
a 5-week treatment period, aortic superoxide (O2-) production was measured in the
lucigenin chemiluminescence assay. Chemiluminescence signals significantly decreased
in sesamin-containing diet-fed DOCA-salt hypertensive rats compared with those in
the normal diet-fed DOCA-salt rats, although the signals in sham-operated control
animals were not affected by the sesamin feeding. In addition, there was a positive
correlation between systolic blood pressure and aortic O2- production. These findings
suggest that sesamin feeding inhibits enhanced vascular O2- production in DOCA-salt
hypertensive rats and that the antioxidative action of sesamin may contribute to
its antihypertensive activity.
Nakano D, Itoh C, Ishii F, et al. Effects of sesamin on aortic
oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt
hypertensive rats. Biol Pharm Bull. 2003;26(12):1701-5.
Sesamin & Lingnas In Fish Oil Study Abstract Sesamin & Lingnas In Fish Oil
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki,
Osaka, Japan.
In the present study, we evaluated the relationship between the antihypertensive
effect of sesamin, a lignan from sesame oil, and its antioxidative activity in deoxycorticosterone
acetate (DOCA)-salt hypertensive rats. After a 5-week treatment period, systolic
blood pressure was significantly elevated in normal diet-fed DOCA-salt animals compared
with cases in sham-operated animals. Sesamin feeding, tempol (a superoxide dismutase
mimetic) treatment or antihypertensive drugs combination (triple therapy; reserpine,
hydralazine, hydrochlorothiazide) significantly suppressed the development of DOCA-salt-induced
hypertension. Compared with sham-operated rats, the normal diet-fed DOCA-salt rats
revealed marked increases in aortic superoxide (O(2)(-)) production. These increases
in O(2)(-) production were significantly suppressed by sesamin feeding or tempol
treatment, but not by triple therapy. Acetylcholine (Ach)-induced endothelium-dependent
relaxation was markedly decreased in normal diet-fed DOCA-salt rats, compared with
cases in sham-operated rats.
Sesamin feeding and triple therapy significantly improved
Sesamin feeding and triple therapy significantly improved
the DOCA-salt-induced impairment of endothelium-dependent relaxation. However, tempol
treatment had no effect on the impaired vasodilator responses induced by DOCA-salt
treatment. In DOCA-salt rats with or without sesamin feeding, systolic blood pressure
significantly correlated with both aortic O(2)(-) production and endothelium-dependent
vascular relaxation. These findings suggest that sesamin feeding inhibits the enhancement
of aortic O(2)(-) production in DOCA-salt hypertensive rats, and this effect may
contribute to the antihypertensive effect of sesamin. Sesamin feeding-induced improvement
of endothelial dysfunction seems to result from the above antioxidative and antihypertensive
effects.
Sankar D, Sambandam G, Rao MR, Pugal- endi KV. Impact of sesame
oil on nifedipine in modulating oxidative stress and electrolytes in hypertensive
patients. Asia Pac J Clin Nutr. 2004;13(Suppl):S107.
Sesamin feeding and triple therapy significantly improved
- Study Abstract
The aim of the study was to investigate the effect of sesame oil as sole edible
oil in hypertensive patients who were on medication with nifedipine, a calcium channel
blocker. A sample of 396 hypertensive patients (aged 58 +/- 3.8 years; 215 men and
181 women) participated in this study. Forty patients were treated only with nifedipine
while three hundred and fifty six patients were treated with nifedipine and instructed
to use sesame oil in place of other edible oils for 60 days. The consumption of
sesame oil remarkably reduced the (systolic and diastolic blood pressure from 166
+/- 4.2 and 101 +/- 3.1 to 134.2 +/- 3.4 and 84.6 +/- 3.0 respectively) blood pressure.
The dosage of the drug also reduced, as there was a fall in blood pressure during
sesame oil consumption.
The best fish oils prove vital to health in America..... Sesamin & Lingnas In Fish Oil <____More Information
Plasma levels of sodium decreased while potassium and chloride
increased significantly. Lipid peroxidation (thiobarbituric acid reactive substances)
level significantly decreased while activities of enzymic (superoxide dismutase,
glutathione peroxidase and catalase) and concentrations of non-enzymic antioxidants
(vitamin C, vitamin E, beta-carotene and reduced glutathione) increased in nifedipine
- sesame oil group. Nifedipine group showed a significant reduction in blood pressure,
lipid peroxidation and improvement in reduced glutathione, however, the values are
significantly lower than nifedipine - sesame oil group. These results suggest that
dietary substitution of sesame oil, in nifedipine-taking hypertensive patients,
has an additive effect in the reduction of blood pressure and plays an important
role in the modulation of electrolytes and in the reduction of lipid peroxidation
and elevation of antioxidants.
Sesamin & Lingnas In Fish Oil <____More Information |
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